ZIA CP010131-04134 (ZIA) | |||
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Title | Radiation dose- response and second primary cancers of stomach, esophagus, and pa | ||
Institution | NCI, Bethesda, Ma | ||
Principal Investigator | Morton, Lindsay | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $482,705 | Project Dates | 05/01/2001 - N/A |
Fiscal Year | 2011 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Cancer Survivorship (100.0%) |
Breast (8.0%) Cervical Cancer (7.0%) Esophagus (15.0%) Hodgkins disease (15.0%) Pancreas (15.0%) Stomach (20.0%) Testes (10.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
The mission of the Radiation Epidemiology Branch (REB) is to identify, quantify, and understand the risk of cancer in populations exposed to radiation, alone or in combination with other agents, such as cytotoxic drugs. This includes research directed to filling important gaps in our knowledge of the relation between radiation dose and site-specific carcinogenesis. In the proposed initiative, REB will provide new information on the relation between radiation dose and cancer risk for three gastrointestinal (GI) organs (stomach, esophagus, and pancreas) for which few quantitative data exist. The study will also supply important new information relevant to clinical decision-making, as it will be undertaken in cancer survivors, and constitutes the first analytic investigation of second GI tumors incorporating information on radiation dose and chemotherapy. This setting will also permit REB to address a major goal in the Branch Strategic Plan - research directed to improving the scientific community's understanding of multiple primary cancers. |